Articles tagged Human Disease
(81 results)

The Neanderthal genome included harmful mutations that made the hominids around 40% less reproductively fit than modern humans, according to estimates published in the latest issue of GENETICS. Non-African humans inherited some of this genetic burden when they interbred with Neanderthals, though much of it has been lost over time. The results suggest that these harmful…

American titans of industry are approaching the business of medical philanthropy just as they do their day jobs: in a big way. It’s not unusual to hear of gifts in the hundreds of millions of dollars, if not the occasional one with close to yet another digit to the left. The inevitable institutes and research…

Fruit flies that devote an excessive amount of time to grooming themselves could serve as a powerful tool for understanding the inherited disorder neurofibromatosis, type 1 (NF-1), report researchers in the latest issue of G3: Genes|Genomes|Genetics.     NF-1 leads to the development of benign tumors in the peripheral nervous system. Common complications of  NF-1…

In preparation for The Allied Genetics Conference (TAGC), set to take place in Orlando this July, Genes to Genomes is getting the inside scoop from many of the outstanding keynote speakers in our “Behind the Podium” series. Here, GSA member Sarah Neuman interviews National Institutes of Health Director, Francis Collins.     As the former…

  Bess Frost submitted the second abstract for The Allied Genetics Conference (TAGC), less than 30 minutes after the first submission. Find out more about her work and why she’s coming to TAGC.   Bess Frost, PhD Assistant Professor Barshop Institute for Longevity & Aging Studies University of Texas Health Science Center at San Antonio Faculty…

New Faculty Profiles showcase GSA members who are establishing their first independent labs. If you’d like to be considered for a profile, please complete this form on the GSA website.   Santhosh Girirajan Assistant Professor (since 2012) Department of Biochemistry and Molecular Biology Department of Anthropology The Pennsylvania State University Lab website Twitter: @GirirajanLab   Research program:…

Short-read sequencing has fueled the acceleration of genetic research But though these next-generation methods are fast and efficient, they can’t do everything well. One important area in which short-reads fall short is detecting structural variants (SV), where chunks of the genome are deleted, inserted, repeated, inverted, or in some other way shuffled around compared to…

If you’ve ever watched a procedural crime-solving show on television, you’re sure to have seen a lab tech magically produce results from a complicated assay in mere minutes. If you’re a wet lab scientist, you’ve probably found yourself wishing that “CSI technology” were real so you didn’t have to spend your whole day running PCRs…

Chickens that “chicken out” in unfamiliar surroundings may shed light on anxiety in humans, according to research published in the January 2016 issue of the journal GENETICS. Domestic chickens are much less anxious than their wild cousins, the red junglefowl. The new research identifies genes that contribute to this behavioral variation and reveals that several…

With about 1 in 8 women in the United States expected to develop breast cancer in their lifetime, breast cancer remains the most common malignancy in women. Though heavily studied, its complexity creates significant challenges to diagnosis, prognosis, and treatment. One of the major problems is that causal DNA mutations of the disease vary from…

The mutations that drive cancer formation are often found in “hub” genes that regulate many aspects of cell growth and survival. But these key genes are not always good therapeutic targets — some are even considered “undruggable.” In the latest issue of GENETICS, Bailey et al. identify a strategy for fighting cancer cells that carry…