Articles tagged Genetics Journal
(248 results)

Guest post by Daniel G. Taub. With billions of neurons in the human brain, making the right connections during development seems a daunting task. A developing neuron often follows the lead of trailblazers, using existing bundles of axons called axonal tracts as a guide. But how does the original axonal tract get laid down? In…

Check out the August issue of GENETICS by looking at the highlights or the full table of contents! ISSUE HIGHLIGHTS This Month’s Centennial Articles Horvitz and Sulston on Caenorhabditis elegans cell lineage mutants, pp. 1485-1487 Kenneth J. Kemphues Kenneth Kemphues introduces Horvitz and Sulston’s 1980 GENETICS Classic, which demonstrated that systematic mutational analysis could dissect the regulation of the…

The detonation of atomic bombs over the Japanese cities of Hiroshima and Nagasaki in August 1945 resulted in horrific casualties and devastation. The long-term effects of radiation exposure also increased cancer rates in the survivors. But public perception of the rates of cancer and birth defects among survivors and their children is in fact greatly…

For two weeks in the summer of 1953, Motoo Kimura enjoyed a welcome respite from loneliness and the austerity of post-war Japan. Crossing the Pacific from Yokohama to Seattle to commence PhD studies at Iowa State University, Kimura played deck golf, enjoyed full service meals, and napped to the soothing vibrations of the venerable passenger…

Memory is a complex neurological process, and understanding its mechanics rarely yields clear-cut answers. So far, research on the memory-implicated gene HDAC4 has been no exception—in fact, HDAC4’s effects on long-term memory seem completely contradictory. Increased HDAC4 protein in the cell nucleus causes memory deficits, and consistent with this, a human mutation that resulted in…

Lurking in colonies of pathogenic bacteria are drug-resistant mutants. If the colony is exposed to antibiotics, these resistant mutants may survive, but they still face the challenge of recolonizing the host. Their success in this task depends on their diversity; a diverse population is more likely to harbor mutants that can withstand a second threat,…

Got a hot manuscript or a burning question for a GENETICS or G3 editor? Just want to talk about scholarly publishing in general? Here’s how you can track down an editor at The Allied Genetics Conference this week: Watch out for ribbons GENETICS and G3 Editors will be wearing silver “Editor” ribbons on their name…

We hope everyone at The Allied Genetics Conference this week will take the opportunity to attend some presentations outside their “home” genetics community. But we realize that sometimes listening to talks in a new field can feel like visiting a foreign country, with its own language, unfamiliar customs, and insider jokes. If only you had…

Sometimes, the most useful scientific tool is a unique perspective. Leonid Kruglyak is a remarkable example of that fact. He originally trained as a physicist, and his quantitative background was foundational to his successful career in genetics and genomics. Kruglyak’s work focuses on the transmission of complex traits and the genetic basis of phenotypic variation. He…

Check out the July issue of GENETICS by looking at the highlights or the full table of contents! This Month’s Centennial Articles Alfred Sturtevant and George Beadle untangle inversions, pp. 1001-1003 R. Scott Hawley and Barry Ganetzky R. Scott Hawley and Barry Ganetzky introduce Sturtevant and Beadle’s 1936 Classic that explained why inversion heterozygosity in the Drosophila X…

Although some proteins have a single career, many—like Dis3—lead a double life. In the yeast Schizosaccharomyces pombe, loss-of-function mutations in dis3 cause defects in mitosis, implying that Dis3 normally supports cell cycle progression. But perplexingly, results in humans suggest that Dis3 normally slows cell cycle progression: mutations that partially disable dis3 contribute to the development…