Articles tagged Gene Editing
(12 results)

When female Anopheles mosquitoes take a blood meal from someone with malaria, a tiny Plasmodium parasite enters the mosquito’s digestive tract. That parasite can invade the mosquito’s salivary tissues, so when the insect takes another blood meal, the intruder can slip into the next human host and start a new malaria infection. Malaria is a…

Sydney Brenner famously noted that progress in genetics “depends on the interplay between new techniques, new discoveries, and new ideas, probably in that order of decreasing importance.” In the 40 years since those words were recorded, new techniques have propelled the field of molecular biology to heights barely imagined at its inception. This year’s recipient…

A better way to make endogenous reporters in C. elegans CRISPR systems for gene editing have revolutionized biological research, but the method still has limitations. While it is usually straightforward to delete parts of the genome using CRISPR, large insertions can be a challenge. This has been the case even for the nematode Caenorhabditis elegans,…

Biolistic genetic transformation in C. neoformans produces few off-target side effects. While genome editing is a staple of genetics research, there remains anxiety about unintended side effects of genetic transformation, one of the most common longstanding genome-editing techniques. Some researchers fear that the process of introducing exogenous DNA into a cell may cause unwanted mutations,…

Wild yeast aren’t picky about their mates. For Saccharomyces cerevisiae, setting the mood is as simple as providing an abundant supply of nutrients, which prompts each yeast cell to search for another of the opposite mating type. If a lonesome yeast cell can’t find a suitable partner, it’s no problem—it can alternate between mating types,…

Why study human diseases in frogs? For starters, 79% of genes implicated in human disease have orthologs in the African clawed frog Xenopus laevis. Frogs also produce hundreds of embryos that can be grown in a dish, meaning they can be manipulated in ways that are impractical on a large scale in mammals. For example,…

Thanks to more than a hundred years of working with Drosophila melanogaster, geneticists have many powerful tools for precisely manipulating its genes. It has also become a model system for studying speciation and molecular evolution together with the other members of the melanogaster species group: D. simulans, D. mauritiana, D. yakuba, and D. santomea. However,…

Fruit fly larvae have one goal: eat as much as possible. After the tiny worm-like larvae hatch from eggs embedded into the flesh of rotting fruit, they eat their way out. After days of gorging, they find a good spot to pupate and then emerge as adults. Fruit flies cannot grow after this transformation, however,…

When geneticist Rob Unckless took his son to Lego Club at the local library, he was not expecting to start a new collaboration. The result is the striking piece of science-inspired art that graces the cover of the February issue of GENETICS. Created by artist Kent Smith, “Attack of the 50 Foot Mosquito” was inspired…

Efforts to engineer genomes in wild populations have huge potential for good—but the real world is more complicated than the lab. Until now, humans have never been able to seriously consider how to cheat evolution. But now that the CRISPR/Cas9 system has made genome editing easy and efficient, it might be possible to manipulate the…

Last week, the National Academies of Science and Engineering joined forces with the Chinese Academy of Science and the Royal Society of the United Kingdom to host an International Summit on Human Gene Editing in Washington, DC. Top scholars in genetics, bioengineering, ethics, and law debated the merits of human gene editing; however consensus was far from achieved.…