Articles tagged G3 Journal
(174 results)

Deep within a tumor, sequestered from an adequate blood supply, a cancer cell grows and multiplies. Far beneath Earth’s surface, a microbe lives and thrives in similarly low-oxygen conditions. Generally, oxygen depletion causes serious distress to aerobic organisms—what allows these life forms to survive? The cellular response to hypoxia is massive. Hypoxia alters the expression…

Misfolded proteins can be so toxic that they cause cell death. At least nine neurodegenerative disorders are caused by misfolded proteins with expanded stretches of glutamine residues (polyQ tracts), including the invariably fatal Huntington’s disease. But some organisms are resistant to the harmful effects of these proteins. In the January issue of G3, Leach et…

To boost transcription of a target gene, enhancer sequences must make contact with the gene’s promoter. This crucial meeting is mediated by interacting proteins and the formation of chromatin loops that bring distant enhancers and promoters together. Although it’s clear that enhancers increase transcription this way, the primary mechanisms by which an enhancer’s target genes…

Check out the January issue of G3! Table of Contents Investigations The CgHaa1-Regulon Mediates Response and Tolerance to Acetic Acid Stress in the Human Pathogen Candida glabrata Ruben T. Bernardo, Diana V. Cunha, Can Wang, Leonel Pereira, Sónia Silva, Sara B. Salazar, Markus S. Schröder, Michiyo Okamoto, Azusa Takahashi-Nakaguchi, Hiroji Chibana, Toshihiro Aoyama, Isabel Sá-Correia,…

Towering sugar pine trees dominate the mountain forests of California and Oregon. They are the tallest pine trees in the world, regularly growing to skyscraper heights of over 100 meters. But these forest behemoths are under attack from a very tiny foe: an invasive fungus. White pine blister rust was accidentally introduced to western North…

Do you have whole genome sequence (WGS) data burning a hole in your pocket? Many high-quality WGS datasets languish unpublished and undescribed because they may not always—in isolation—reveal substantial new biological insights. However, the editors of G3: Genes|Genomes|Genetics recognize that WGS data on strain variation, comparative analysis of different model organism species, and other rich…

Each year, emergency departments in the US treat almost 700,000 people for traumatic brain injury (TBI). The outcome depends largely on the severity and location of the injury, but these aren’t the only factors. Age also plays a role, with children often recovering more fully than do adults. The patient’s diet following the injury may…

Check out the December issue of G3! Table of Contents Meeting Report Meeting Report: The Allied Genetics Conference 2016 Organizers of The Allied Genetics Conference 2016 G3 December 2016 6:3765-3786; doi:10.1534/g3.116.036848 Full Text | Full Text (PDF) Investigations Assessing the Gene Content of the Megagenome: Sugar Pine (Pinus lambertiana) Daniel Gonzalez-Ibeas, Pedro J. Martinez-Garcia, Randi…

Recombination within the genome isn’t random. This swapping of DNA segments between one chromosome and its homolog preferentially affects specific genome regions called hotspots. These regions can have recombination rates many times higher than other areas of the genome, and the rapid shuffling of genetic information is thought to be important in evolution. The location…

Sex chromosomes have evolved from autosomes hundreds of times across the tree of life. In mammals, sex is controlled by the Y chromosome-linked gene SRY, which triggers the development of male anatomy. Sex determination in most mammals is extremely conserved; essentially all marsupials and placental mammals share the same pair of X and Y chromosomes…

GENETICS and G3 are excited to welcome new editors! GENETICS and G3 Series Editor: Lauren McIntyre GENETICS Associate Editors: Anne Britt, Elizabeth Hauser, Jennifer Surtees, Paul Scheet, Mikko J. Sillanpää, Mario Calus, Katie Peichel G3 Associate Editors: Michael J. Axtell, Fernando Pardo-Manuel de Villena, Shavannor M. Smith, Joshua Udall GENETICS and G3 Series Editor LAUREN MCINTYRE University of Florida Lauren McIntyre is developing a…