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Articles tagged Fish
(15 results)
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Zebrafish models for one-of-a-kind families
In this month’s editorial, the Editors of GENETICS invite submissions of human genetics research articles. To kick off the journal’s call for papers, the October issue features an article by Brooks and Wall et al. identifying the cause of a single-family disorder and a commentary by Phil Hieter and Kim Boycott on the power of model organisms…
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Know your Fish: A defined zebrafish line for CRISPR:
Zebrafish develop fast. They are conveniently small. Their embryos are stunningly transparent. But despite their many powerful advantages as a genetic model, they have a drawback that complicates the use of methods like CRISPR, morpholino knockdown, and RNAseq: they are not great inbreeders. Because inbred zebrafish stocks tend to be sickly, most research relies on…
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Genetic maps, 100 years later
One feverish night, just over 100 years ago, an undergraduate in Thomas Hunt Morgan’s lab created the first genetic map. Realizing that the frequency of crossing over could be used to work out out the linear order of genes on a chromosome, that student, Alfred Sturtevant, published his map in 1913 and laid the foundation…
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New Fish on the Block
The medaka, or Japanese rice fish, is a century-old genetic model on the rise again. Long studied by scientists in Japan, it has been rediscovered by the wider research community over the last decade as a flexible tool for vertebrate genetics. Part of the appeal is the medaka’s amenability to inbreeding. In the latest issue…