Science & Publishing

Holes in the plasma membrane trigger the activation of the Torso receptor tyrosine kinase. As a general rule, cells don’t do well when holes are poked in their plasma membranes. That’s why many immune cells use enzymes like perforin to puncture the membranes of pathogenic cells, dysregulating and often killing them. However, a new report…

A new genome assembly for Antarctic fur seals sheds light on their historic comeback after 19th century hunting. In the late 19th century, the Antarctic fur seal was thought to be effectively extinct. After over a century of overexploitation driven by demand for the seal’s prized pelt, populations at known breeding grounds seemed to have…

Food-deprivation inhibits the stress-induced sleep response in C. elegans. For many animals, the essential physiological drives of sleep and food are intimately linked. You might have noticed this if you’ve ever stayed up far too late and found yourself craving a snack. Yet because it’s impossible for most animals to eat and sleep at the…

A fruit fly model of fetal alcohol spectrum disorder reveals a Cyclin E-centric network modifies developmental sensitivity. Alcohol exposure in utero can lead to a wide range of developmental problems, even causing fetal death in some cases. But since this exposure doesn’t always have the same outcome, is it more likely to be a problem…

The recipient of the 2018 Crow Award reveals details of flu evolution at the smallest —and largest—scales. For many viral diseases, a vaccine can provide lifelong protection. But for flu, you need a new shot every year. The influenza virus evolves so fast it presents a constantly moving target for both our immune systems and…

Tissue culture causes heritable methylation changes in plants. Tissue culture is a useful tool for plant scientists and horticulturalists in large part because it allows them to produce clones. Inconveniently, however, these clones are not always identical to the original, as one might expect them to be. In a report in GENETICS, Han et al.…

By borrowing a system found in plants, researchers can turn off sperm production in an inducible, reversible, and non-toxic manner Let’s say you want to study how your favorite gene affects aging. You pick Caenorhabditis elegans for your study because it is one of the most important models of aging, and you put some of…

GC content alone is associated with distinct functional classes of human enhancers. Because enhancers can be located hundreds of kilobases away from their target genes, it can be challenging to accurately predict their functions. A new report in GENETICS uses sequence composition to distinguish two enhancer classes that have distinct functions and spatial organization in humans.…

A strain of Staphylococcus epidermidis isolated from a hotel room may provide insight into how resistance develops outside of medical settings. Although intense research and media interest has focused on drug-resistant bacteria in hospital settings, resistance can and does evolve outside the clinic. Methicillin-resistant Staphylococcus epidermidis is often isolated from infections of medical devices, but…

Termites may have evolved sterile castes through hormone signaling changes in their cockroach ancestors. Eusocial insects, like ants, bees, and termites, have rigid caste systems: some individuals reproduce, while others are temporarily sterile workers or permanently sterile soldiers. This division of labor allows colonies to thrive, but the question remains:  how did these species evolve…

An automated drug screening approach gives insight into rare NGLY1 deficiency. Sometimes, diagnosing and treating an illness is straightforward. Other times, the diagnosis is challenging while the treatment is simple—or vice versa. In the case of a rare disease like NGLY1 Deficiency, both diagnosis and treatment can feel unreachable. The complex challenges of rare diseases…