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Science & Publishing

  • First author Christopher Campbell's dog, Lipa.
    Science & Publishing

    Dog pedigrees shed light on recombination

    Recombination within the genome isn’t random. This swapping of DNA segments between one chromosome and its homolog preferentially affects specific genome regions called hotspots. These regions can have recombination rates many times higher than other areas of the genome, and the rapid shuffling of genetic information is thought to be important in evolution. The location…

  • Science & Publishing

    TAGC Videos & Meeting Report: The Allied Genetics Conference online!

    The Allied Genetics Conference was an experiment for the GSA. We brought together under one roof seven separate research community meetings: C. elegans, ciliate, Drosophila, mouse, yeast, zebrafish, and population, evolutionary, and quantitative genetics. Today we are launching another experiment, this time, to communicate results presented at the meeting. Thanks to a generous grant from the…

  • Metamorphosing froglets of Xenopus borealis used in this study. Photo by Adam Bewick.
    Science & Publishing

    Sex chromosome turnover in frogs hints at evolutionary patterns

    Sex chromosomes have evolved from autosomes hundreds of times across the tree of life. In mammals, sex is controlled by the Y chromosome-linked gene SRY, which triggers the development of male anatomy. Sex determination in most mammals is extremely conserved; essentially all marsupials and placental mammals share the same pair of X and Y chromosomes…

  • By 23am.com (Antarctica Sailing Trip) [CC BY 2.0], via Wikimedia Commons.
    Science & Publishing

    Cold-loving fungi fight frostbite, but can’t take the heat

    To the unaided eye, Antarctic soil and alpine glaciers may appear to be barren wastelands devoid of life. But some microbes call hostile habitats like these home. Research on one such organism, published in the latest issue of G3, reveals some of the mechanisms behind cold adaptation—and explains why these otherwise hardy creatures can’t survive…

  • By BMW Werk Leipzig (http://bmw-werk-leipzig.de) [CC BY-SA 2.0 de], via Wikimedia Commons
    Science & Publishing

    Speed limits in bacterial factories

    In the fast-paced life of a bacterium, the ability to manufacture proteins quickly and efficiently is crucial. In these organisms, mRNAs—the templates for building proteins—have a string of bases near the start called the Shine-Dalgarno (SD) sequence. This motif increases the rate at which translation is initiated. Some results suggest that the presence of SD…

  • Seizures are caused by surges of uncontrolled electrical activity in the brain. Photo by Michael Coghlan via Flickr.
    Science & Publishing

    High Temperatures Suppress Seizures in a Fruit Fly Epilepsy Model

    The human brain is an amazing machine powered by electricity. Carefully controlled patterns of changing electrical charges in neurons allow us to to think, move, and speak. When this system is disrupted, very bad things happen. A seizure occurs when a sudden surge of electrical activity in the brain interrupts normal functioning. Seizures are accompanied…

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    November GENETICS Highlights

    Check out the November issue of GENETICS by looking at the highlights or the full table of contents! ISSUE HIGHLIGHTS This Month’s Centennial Articles Charlesworth et al. on background selection and neutral diversity, pp. 829-832 Stephen I. Wright Associate Editor Stephen I. Wright introduces the 1993 GENETICS Classic by Charlesworth. This landmark article revealed an important effect structuring neutral…

  • dionne-et-al
    Science & Publishing

    New in G3: maize, master regulators, and mutagenesis

    Check out the November issue of G3! Table of Contents Investigations Genomic Prediction of Single Crosses in the Early Stages of a Maize Hybrid Breeding Pipeline Dnyaneshwar C. Kadam, Sarah M. Potts, Martin O. Bohn, Alexander E. Lipka, and Aaron J. Lorenz G3 November 2016 6:3443-3453; Early Online September 19, 2016 doi:10.1534/g3.116.031286 Abstract | Full…

  • Photo courtesy of Ludovic Orlando. Przewalski’s horses went extinct in the wild in 1969, but have since been reintroduced to Mongolia.
    Science & Publishing

    The Genetic History of Horses

    Like any revolutionary technology, domestic horses changed human society. The incredible speed and strength of these animals opened up new opportunities to spread trade, language, and culture. For thousands of years, horses have been helping build human society by pulling wagons and plows and carrying soldiers and travelers on their backs. Horse husbandry changed humanity,…

  • BI 6727, A Polo-like Kinase Inhibitor with Improved Pharmacokinetic Profile and Broad Antitumor Activity. Dorothea Rudolph, Martin Steegmaier, Matthias Hoffmann, Matthias Grauert, Anke Baum, Jens Quant, Christian Haslinger, Pilar Garin-Chesa and Günther R. Adolf. Clin Cancer Res May 1 2009 (15) (9) 3094-3102; DOI: 10.1158/1078-0432.CCR-08-2445
    Science & Publishing

    Using yeast to expose cancer’s genetic vulnerabilities

    Cancer profoundly scars the genome of an affected cell. Amplification and overexpression of chunks of DNA sequence are common—but it’s not always clear whether these changes are directly involved in the disease or byproducts of some other malfunction. Further complicating the search for treatments, many genes that are altered in cancer cells are involved in…

  • Science & Publishing

    GSA Journals Spotlight 2015

    The GSA Journals, GENETICS and G3: Genes|Genomes|Genetics, are proud to present our annual Spotlight booklets for research published in 2015. Each Spotlight is a showcase of the excellent research and scholarship published over the course of the year, along with a selection of striking images submitted by our authors. Browse the 2015 GENETICS Spotlight. Browse the 2015 G3 Spotlight.      …